What could go wrong in the best man speech? As the best man you should be aware of many possible mishaps to the best man speech.  The most common would be an audience disturbance from patrons who are socially engaged and do not realize to be quiet and respectful when the best man speech is going on.  A proper introduction of the best man  by the DJ or some kind of a master of ceremonies is the best way to avoid this mishap to your best man speech.  If there is nobody who seems to be the right fit as a ceremonies master than the perfect person for the job is you, the best man.  Any other wedding toasts or remarks that are to be made by the groom, bride, and bridesmaid can be made before the best man speech, and then you can end the speaking portion of the meeting with your best man speech.